Abstract: To determine the acute oral toxicity and genetic toxicity of resveratrol (Res)，so to provide experimental basis for its application. METHODS：Acute oral toxicity test was performed in mice. The genetic toxicity of Res was evaluated by Ames test(Res doses at 5 000，1 000，200，40，8 μg each dish)，bone marrow micronucleus test and sperm shape abnormality test (Res was administered to mice at 7.500，3.750，1.875 g/kg doses). RESULTS：The acute oral maximum-tolerated dose(MTD) of resveratrol was greater than 15.0 g/kg. Ames test，micronucleus test and sperm shape abnormality test showed negative results. CONCLUSION：In our experimental context，resveratrol was classified as non-toxic substance. It did not produce genetic toxicity.

Key words: resveratrol, mouse, acute oral toxicity, genetic toxicity